Light-Sheet Microscope to Monitor 3D Protein Distribution in Large Biological Samples
The 3D recording of proteins in entire organ systems represents a technical challenge. The technique developed for this microscope makes it now possible to illuminate a larger object (e.g. entire organs) from the side with fluorescent light (shaped as a light-sheet) and to detect the signals. With this arrangement, a larger object can be captured in its entirety by the light-sheet completely scanning the object. ReALity funds supplemented the DFG application of several groups at UMC to acquire this powerful state-of-the-art light-sheet microscope. Its installation and running will be managed by the Institute of Physiological Chemistry. This novel technology can now be applied to numerous projects and presents a big asset to the Mainz research community. The microscope can be booked through openiris.
