We support the developing excellence of research aimed at:
- Understanding responses to system specific decline
- Defining intrinsic and environmental challenges to healthy aging
- Exploring system robustness and cellular plasticity as a resilience mechanism
- Identifying vulnerable cellular and molecular interactions in aging
- Deciphering how interventions targeting one system influence other systems
Successful applications should establish a clear link to the above-mentioned themes, interconnect focus areas and broadly support ReALity goals with visible results within the next 3-4 years.
Please contact us for further information about the application process for recruitment and infrastructure support.
The close link between data generation and analysis is one of the core features of the ReALity initiative. ReALity has supported the recruitment of Prof. Susanne Gerber to a W2 position for clinical genomics and bioinformatics at the University Medical Center. Prof. Gerber is a young biomathematician with a focus on omics analysis and the processing of complex data sets with small sample sizes. Her recruitment has filled a substantial gap at the UMC and JGU and reaches out into all focus areas.
Computational Systems Genetics Group, headed by Susanne Gerber
Dr. Lukas Stelzl – Institute of Molecular Physiology, JGU/Institute of Molecular Biology
ReALity recruited Dr. Stelzl to the JGU as a junior group leader with associate group leader status at the IMB. He is biochemist by training and his research focuses on how liquid-liquid phase separation of disordered proteins and nucleic acids regulates cellular processes and how this affects longevity and ageing using innovative multi-scale simulations and data science, including artificial intelligence. With his expertise, he bridges a deep understanding of biophysical experiments (NMR, single-molecule FRET, EPR and SAXS) and multi-scale simulations, a strong background in biology and the ability to design and implement novel algorithms. Together with collaboration partners at JGU/IMB and within the Rhine-Main University consortium, he will push forward biochemical research on cellular regulation by phase-separation and Cell Biology 2.0, thereby enriching the core units of ReALity and the Institute for Quantitative Biomedicine.
Web page of the Institute of Molecular Biology on Lukas Stelzl
ReALity supports the ongoing expansion of the Gnotobiotic Mouse Facility at JGU that enables innovative studies on the complex roles microbiota in the adaptation and resilience of cardiovascular, immune, and neuronal systems. This facility was established in Mainz by Jun.-Prof. Christoph Reinhardt who recently received a JGU Gutenberg Research Council Fellowship. As a GRC fellow, he will continue to develop this research area and broaden conceptually the links between immunology and vascular biology.
Metabolism is tightly regulated across scales: in each cell type, organ and organism. In turn, metabolic processes and their (by)-products have substantial impact on cellular and organ functions; thereby affecting all research fields from neurology, immunology, endocrinology, oncology to cardiovascular research. Interdisciplinary research on metabolism will help to understand crucial mechanisms of adaptation, resilience and longevity, the key aspects of ReALity. The Seahorse Analyzer funded by ReALity will provide the basis of a live-cell metabolic platform open to all ReALity researchers. The expertise of Dr. Luciana Berod and her team will be essential to establish SOPs required for various cell types of interest and scientific research questions. Together with Prof. Tenzer (FZI, Institute Immunology), the Lipidomics Unit (Prof. Beat Lutz/Dr. Bindila, Institute of Physiological Chemistry) and the Center for Thrombosis and Hemostasis (Prof. Ruf), the metabolic research platform with its focus on immunometabolism will reinforce the metabolism thematic for quantitative biomedicine in Mainz.
RNA modifications are linked to a variety of health problems and are often associated to age-related dysfunctions including, but not limited to, neurogenerative diseases. Dr. Winz, who was recently recruited to Mainz, has long-standing expertise in the field of RNA research with a focus on co-translational quality control. Collaborative projects within several research initiatives in Mainz are already planned or established. The equipment for gradient centrifugation, fractionation, and UV crosslinking funded by ReALity will be the basis for establishing polysome isolation techniques in Mainz. This will foster the above-mentioned interactions with RNA research groups and play a key role for interdisciplinary research at the center of ReALity research areas.
In order to expand this unique research tool and to allow for in-depth analyses across scales, ReALity supports expansion of the existing liquid biorepository by the establishment of a cryopreserved viable peripheral blood cell bank accessible for all Mainz life science researchers across disciplines. This expansion allows for in-depth and cell-based OMICS analyses and adds a new level on the already existing and ever-growing multi-level biodata present in this unique infrastructure.
Website of the Gutenberg COVID-19 study